| Year | Date | Events |
| 1841 | 22 April | "Hong Kong with the surrounding six leagues" was established as a Prefecture Apostolic, independent from Macao Diocese, with Fr. Theodore Joset, a Swiss diocesan priest who was the Sacred Congregation of Propaganda Fide's representative in Macao, as the first Prefect Apostolic; the first need being the spiritual care of the British (Irish Catholic) Troops, stationed in the just occupied Colony. |
| 1842 | 22 January | Fr. Michael Navarro, a Spanish Franciscan, took up residence as the first Catholic priest in the Colony. |
| 3 March | Arrival of Fr. Joset with other priests and seminarians expelled from Macao. | |
| 7 June | Laying of the foundation stone of the first Church (in Wellington Street) dedicated to the Immaculate Conception (blessed on 11 June 1843, enlarged in 1858-59, burnt down on 18 October 1859, rebuilt and blessed on 18 March 1860). | |
| 5 August | Death of Fr. Joset. | |
| 11 December | Fr. Anthony Feliciani, an Italian Franciscan, appointed new Prefect Apostolic. | |
| 1843 | 1 February | First school for Chinese boys started. |
| 1844 | Mission work spread to Stanley and Chaiwan. | |
| 1845 | St. Francis Chapel built in Wanchai. | |
| 1846 | The local Seminary started (called Immaculate Conception Seminary in 1888, moved to new premises in front of the Cathedral in 1900). | |
| 1847 | 5 October | Mgr. Augustin Forcade, MEP, Vicar Apostolic of Japan, appointed also Pro-Prefect of Hong Kong, helped by other MEP Missionaries, who had just transferred their Procure from Macao. |
| 1848 | 12 September | The first group of St. Paul de Chartres Sisters arrived: took care at once of the foundlings and then of sick and old people in the Asile de la St. Enfance, Wanchai (St. Paul's Institutions, in Tonglowan, were officially opened on 6 October 1916). |
| 1849 - 50 | Mission work started in Aberdeen and Tsuen Wan. |