| Year | Date | Events |
| 1860-61 | The boundaries of the Prefecture having been enlarged to include the whole San On District (later, Po On), mission work spread to Kowloon Peninsula (exploratory trips of the inland area: December 1860 and April 1861), to Tai Po area, Sai Kung Peninsula, Nam Tau, etc. (1863-67). | |
| 1860 | 12 April | Arrival of the first Canossian Sisters, who started with educational and social services, soon joined by Chinese ladies as Tertiaries (later, Precious Blood Sisters): Sacred Heart English School (10 May 1860), Pui Ching Chinese School (10 May 1860). |
| 1861 | Dominican Fathers established their Procure (started the Noviciate in 1924 and the House of Studies in 1935). | |
| 1863 | West Point Reformatory opened. | |
| 12 July | St. Vincent de Paul Society established. | |
| 1864 | Holy Saviour's College opened. | |
| 1867 | 10 March | Death of Prefect Ambrosi. |
| 17 November | Fr. Raimondi appointed as successor, with full responsibility for the Prefecture passing to PIME. |