| Year | Date | Events |
| 1920 | Beginning of missionary work in Tai O (Lantao Island). | |
| 15 September | "The Rock", a Catholic English language monthly, launched. | |
| Arrival of Maryknoll Fathers who established their Procure and took charge of the St. Louis Industrial School (former West Point Reformatory and Orphanage) from 1921 to 1926; and pastoral work since 1952. | ||
| 1921 | Maryknoll Sisters arrived for educational and pastoral work (MM Convent School in 1925). | |
| 1922 | Precious Blood Sisters started as independent Congregation from the Canossians (juridically established as such on 19 July 1929); in Sham Shui Po since 1929; the Precious Blood Hospital opened in 1937. | |
| 1923 | 2 February | Little Sisters of the Poor arrived to take care of the Home for the Aged in Kowloon (and then in Aberdeen in 1962). |
| 1924 | 20 February | Death of Bishop Pozzoni; Fr. J.M. Spada elected Vicar Capitular. |
| 1925 | 25 January | Blessing of St. Margaret Mary's Church, Happy Valley (erected as a parish on 25 January 1949). |
| 1926 | 8 March | Fr. Henry Valtorta appointed as 4th Vicar Apostolic (consecrated bishop on 13 June). |
| 1 May | New Territories divided into 3 eccl. districts: East (Sai Kung), West (Taipo) and Islands. | |
| 3 December | Arrival of the Jesuit Fathers, who opened Ricci Hall Hostel (1929), took charge of the South China Regional Seminary (1931) and of Wah Yan College (1932). | |
| Canadian Sisters of Our Lady of the Angels arrived for educational work (St. Clare's School: 1927). | ||
| 1927 | 1 October | Salesian Fathers arrived: took charge of the St. Louis Industrial School. |
| 1928 | 19 March | Opening of St. Joseph's Hospital in Waichou. |
| 4 August | "Kung Kau Po", a Catholic Chinese language weekly, founded by Fr. A. Granelli. | |
| Canadian Sisters of the Immaculate Conception arrived for educational work (Tak Sun School: 1928). | ||
| 1929 | Precious Blood Church, Sham Shui Po, opened (divided from Rosary and St. Teresa's Churches in 1933, rebuilt in 1937, erected as a parish on 25 January l949). |